Modern management of anal fistula

Table 3 Published studies on GORE BioA fistula plug

Ref.	Study design	No. patients	Aetiology and classification	Healing-rate	Follow-up (mo)	Complications
Buchberg et al[61]	Retrospective	10	6 cryptoglandular	54%	2	NR
	Case-series		3 iatrogenic
			1 HIV
de la Portilla et al[62]	Prospective	19	10 high- transphincteric	16%	12	1 Acute sepsis
	Case-series		9 low transphicteric			1 Urge incontinence
						1 Plug extrusion
Ratto et al[63]	Prospective	11	11 High-	73%	5	NR
	Case-series		transphincteric
Ommer et al[64]	Retrospective	40	28 High-transphincteric	57.5%	12	1 Plug extrusion
	Case-series		12 Suprasphincteric			1 abscess
			4 Crohn’s			1 Dehiscence