Fecal microbiota transplantation broadening its application beyond intestinal disorders

Table 1 Summary of extra-intestinal disorders associated with gut microbiota

Extra-intestinal disorders	Ref.	Publication year	Study type
Metabolic diseases
Metabolic syndrome	Vrieze et al[61]	2012	RCT1
Obesity	Turnbaugh et al[54]	2009	Observational study
	Armougom et al[56]	2009	Observational study
	Schwiertz et al[55]	2010	Observational study
	Greenblum et al[53]	2012	Observational study
	Parks et al[52]	2013	Experimental study
Type 2 diabetes mellitus	Qin et al[59]	2012	Observational study
Cardiovascular diseases	Wang et al[62]	2011	Experimental study
	Tang et al[65]	2013	Experimental study
	Koeth et al[66]	2013	Experimental study
Non-alcoholic fatty liver	Rabot et al[73]	2010	Experimental study
	Le Roy et al[68]	2013	Experimental study1
Neuropsychiatric disorders
Parkinson’s disease	Ananthaswamy[74]	2011	Case report1
Multiple sclerosis	Borody et al[76]	2011	Case report1
Myoclonus dystonia	Borody et al[78]	2011	Case report1
Autism	Finegold et al[79]	2002	Observational study
	Song et al[82]	2004	Observational study
Chronic fatigue syndrome	Borody et al[84]	2012	Cohort study1
	Frémont et al[83]	2013	Observational study
Autoimmune disorders
ITP	Borody et al[85]	2011	Case report1
Arthritis	Scher et al[88]	2013	Observational study
	Abdollahi-Roodsaz et al[86]	2014	Experimental study
SS and SLE	Szymula et al[91]	2014	Experimental study
Hashimoto’s thyroiditis	Corapçioğlu et al[93]	2002	Observational study
	Strieder et al[92]	2003	Observational study
	Sasso et al[96]	2004	Observational study
	Effraimidis et al[95]	2011	Observational study
Allergic disorders
Atopy	Dotterud et al[107]	2010	RCT
	Herbst et al[101]	2011	Experimental study
	Schabussova et al[105]	2012	Experimental study
Asthma	Jang et al[104]	2012	Experimental study
	Stensballe et al[102]	2013	Observational study
Extra-intestinal tumors	Gold et al[15]	2004	Observational study
Mammary tumors	Rao et al[111]	2006	Experimental study
	Rao et al[112]	2006	Experimental study
Hepatocellular carcinoma	Fox et al[114]	2010	Experimental study
Lymphoma	Yamamoto et al[115]	2013	Experimental study

¹Fecal microbiota transplantation used in these studies. RCT: Randomized controlled trial; ITP: Idiopathic thrombocytopenic purpura; SS: Sjögren's syndrome; SLE: Systemic lupus erythematosus.