Involvement of substance P and the NK-1 receptor in pancreatic cancer

doi:10.3748/wjg.v20.i9.2321

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Mar 7, 2014 (publication date) through Nov 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2014; 20(9): 2321-2334
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2321

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Figure 1 Substance P and neurokinin-1 receptor antagonists bind to different sites of the neurokinin-1 receptor. Substance P (SP) binds to the extracellular loops of the receptor, whereas neurokinin-1 (NK-1) antagonists (e.g., L-733.060, aprepitant, L-732.138) bind more deeply, between the transmembrane segments.

Citation: Muñoz M, Coveñas R. Involvement of substance P and the NK-1 receptor in pancreatic cancer. World J Gastroenterol 2014; 20(9): 2321-2334
URL: https://www.wjgnet.com/1007-9327/full/v20/i9/2321.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i9.2321