Copyright
©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2014; 20(9): 2279-2303
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2279
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2279
Table 2 Oncogenes and tumor suppressor genes, whose products participate in regulation of cancer cells metabolism
Oncogene/tumor suppressor | Metabolic pathway | Enzyme | Ref. |
MYC | Glucose transport | GLUT1 | [53-55] |
Glycolysis | Hexokinase 2 | ||
Phosphohexose isomerase | |||
Phosphofructokinase 1 | |||
Aldolase A | |||
3-phosphoglyceraldehyde dehydrogenase | |||
Phosphoglycerate kinase | |||
Phosphoglycerate mutase | |||
Enolase 1 | |||
Pyruvate kinase 2 | |||
Lactate dehydrogenase A | |||
Regulation of PDH | Pyruvate dehydrogenase kinase 1 | ||
Glutamine transport | Glutamine transporters ASCT2 and SN2 | ||
Glutaminolysis | Glutaminase 1 | ||
Serine hydroxymethyltransferase | |||
Pyrimidine synthesis | |||
Aminoacids metabolism | CAD | ||
Ornithine decarboxylase | |||
Lipogenesis | Fatty acid synthase | ||
p53 | Glucose transport | GLUT1 | [51,56-60] |
Glycolysis | Hexokinase 2 | ||
Fructose-2,6-bisphosphatase | |||
Phosphoglycerate mutase | |||
Oxidative phosphorylation | Cyrochrome c oxidase | ||
Glutaminolysis | Glutaminase 2 | ||
Pentose Phosphate Pathway | Glucose-6-phosphate dehydrogenase | ||
Regulation of PDH | Pyruvate dehydrogenase kinase 1 | ||
Krebs cycle | Aconitase | ||
KRAS | Glucose transport | GLUT1 | [61,73,94] |
Glycolysis | Hexokinase 2 | ||
Phosphofructokinase 1 | |||
Lactate dehydrogenase A | |||
Pentose phosphate pathway | Transketolase | ||
Hexosamine synthesis | Phosphohexose aminotransferase | ||
Glutaminolysis | Glutamate dehydrogenase | ||
Aspartate transaminase | |||
Akt/PTEN | Glucose transport | GLUT1 | [50,113-115] |
Lipogenesis | FASN |
- Citation: Swierczynski J, Hebanowska A, Sledzinski T. Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. World J Gastroenterol 2014; 20(9): 2279-2303
- URL: https://www.wjgnet.com/1007-9327/full/v20/i9/2279.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i9.2279