Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer

Table 1 Overexpression of lipogenic enzymes in human tumors

Enzyme name	Neoplasm type	Experimental model	Ref.
Fatty acid synthase (FASN)	Pancreatic cancer	Human tumor tissue, cell line	[96,104,105]
	Breast carcinoma	Human tumor tissue	[5,9,166]
	Prostate cancer	Human tumor tissue	[167]
	Melanoma	Human tumor tissue	[168]
	Nephroblastoma	Human tumor tissue	[169]
	Renal cancer	Cell line	[170]
	Endometrial carcinoma	Human tumor tissue	[12,171]
	Colon cancer	Human tumor tissue	[11,172]
	Ovarian neoplasms squamous cell	Human tumor tissue	[10,173]
	Carcinoma of the lung head and neck squamous	Human tumor tissue	[174]
	Cell carcinoma squamous cell	Human tumor tissue	[175]
	Carcinoma of the tongue	Human tumor tissue	[176]
ATP citrate lyase (ACLY)	Small cell lung cancer	Cell line	[251]
	Bladder cancer	Human tumor tissue	[7]
	Breast cancer	Cell line	[252]
	Gastric cancer	Human tumor tissue, cell line	[253]
	Colon cancer	Human tumor tissue	[254]
	Prostate cancer	Human tumor tissue	[254]
	Hepatocellular carcinoma	Human tumor tissue	[255]
Acetyl-CoA carboxylase (ACCA)	Prostate cancer	Human tumor tissue	[6]
	Hepatocellular carcinoma	Human tumor tissue	[255]
	Breast carcinoma	Human tumor tissue	[256]
Stearoyl-CoA desaturase (SCD1)	Pancreatic cancer	SCD1 indices in patients serum	[128]
	Clear cell renal cell carcinoma	Human tumor tissue	[200]
Acetyl-CoA synthetase (ACS)	Colon adenocarcinoma	Human tumor tissue	[257]
	Malignant glioma	Cell line	[258]
Citrate synthase (CS)	Pancreatic cancer	Human tumor tissue	[19]
	Renal cell carcinoma	Human tumor tissue	[20]