Systematic review of novel ablative methods in locally advanced pancreatic cancer

doi:10.3748/wjg.v20.i9.2267

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2014; 20(9): 2267-2278
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2267

Table 5 Studies of photodynamic therapy in pancreatic ductal adenocarcinoma

Study	n	Study	Photosensitiser	Number of fibres	Number of ablations	Outcome and survival	Complications
Bown et al[30]	16	CT guided percutaneous PDT to locally advanced but inoperable PDAC without metastatic disease	mTH-PC	Single	1	Tumour necrosis: 16/16. Median survival: 9.5 mo. 44% (7/16) survived > 1 year	Significant gastrointestinal bleeding: 2/16 (controlled without surgery)
Huggett et al[31,32]	13 + 2	CT guided percutaneous PDT to locally advanced but inoperable PDAC without metastatic disease	Verteporfrin	Single (13) Multiple (2)	1	Technically feasible: 15/15. Dose dependent necrosis occurred	Single fibre: No complications. Multiple fibres: CT evidence of inflammatory change anterior to the pancreas, no clinical sequelae

PDAC: Pancreatic ductal adenocarcinoma; CT: Computed tomography.

Citation: Keane MG, Bramis K, Pereira SP, Fusai GK. Systematic review of novel ablative methods in locally advanced pancreatic cancer. World J Gastroenterol 2014; 20(9): 2267-2278
URL: https://www.wjgnet.com/1007-9327/full/v20/i9/2267.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i9.2267