Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

Figure 4 Differences in histological parameters during experimental colitis. Colons were collected from DSS-treated mice on days 3 (B), 7 (C) 13 (D), 19 (E) and 29 (F). In comparison to control mice (A), histopathological changes in individual crypts are shown in representative hematoxylin and eosin-stained sections. Loss of crypt architecture associated with epithelial damage and flattened villi (red arrows) and leukocyte infiltration (black arrows) are evident following DSS treatment (bar = 200 μm).