Perioperative anemia management in colorectal cancer patients: A pragmatic approach

Table 3 Some characteristics of the different intravenous iron formulations

	Iron gluconate	Iron sucrose	High molecular weight iron dextran	Low molecular weight iron dextran	Ferric carboxymaltose	Iron isomaltoside 1000	Ferumoxytol
Brand name	Ferrlecit®	Venofer®	Dexferrum®	Cosmofer®	Ferinject®	Monofer®	Rienso®
				INFeD®	Injectafer®		FeraHeme®
Carbohydrate shell	Gluconate (monosaccharide)	Sucrose (disaccharide)	Dextran (branched polysaccharide)	Dextran (branched polysaccharide)	Carboxymaltose (branched polysaccharide)	Isomaltoside (linear oligosaccharide)	Polyglucose sorbitol carboxymethylether
Molecular weight (kDa)	289-440	30-60	265	165	150	150	750
Plasma half-life (h)	1	6	60	20	16	20	15
Direct iron donation to transferrin (% injected dose)	5-6	4-5	1-2	1-2	1-2	< 1	< 1
Test dose required1	No	Yes/No	Yes	Yes	No	No	No
Iron content (mg/mL)	12.5	20	50	50	50	100	30
Maximal single dose (mg)	125	200-300	20 mg/kg	20 mg/kg2	20 mg/kg (max 1000 mg in one infusion)	20 mg/kg	5103
Premedication	No	No	TDI only	No	No	No	No
Life-threatening ADE (× 106 doses)	0.9	0.6	11.3	3.3	??	??	??

¹A test dose is no longer recommended by the European Medicines Agency (2013);

²Low molecular weight iron dextran can be safely administered at doses of 1000 mg over 1 h[101];

³Preliminary data indicate that Ferumoxytol may be administered at doses of 1020 mg over 15 min[102].