New genes emerging for colorectal cancer predisposition

doi:10.3748/wjg.v20.i8.1961

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Feb 28, 2014 (publication date) through Jan 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2014; 20(8): 1961-1971
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1961

Table 1 Hereditary colorectal cancer genes

	Gene	Chromosome	Mendelian pattern	Function
Familial adenomatous polyposis	APC	5q	AD	Regulation of canonical Wnt signaling pathway
Familial adenomatous polyposis	MUTYH	1p	AR	Base-excision repair
Hereditary non-polyposis CRC (Lynch syndrome)	MLH1	3p	AD	Mismatch repair
	MSH2	2p	AD	Mismatch repair
	MSH6	2p	AD	Mismatch repair
	PMS2	7p	AD	Mismatch repair
Peutz-Jeghers	LKB1	19p	AD	Regulation of Wnt signaling pathway
Juvenile polyposis	SMAD4	18q	AD	TGFBR signaling pathway
Juvenile polyposis	BMPR1A	10q	AD	TGFBR signaling pathway
Cowden’s disease	PTEN	10q	AD	Negative regulation of PI3K signaling
Cowden’s disease	KLLN	10q	AD	Apoptotic process

CRC: Colorectal cancer; AD: Autosomal dominant; AR: Autosomal recessive; TGFBR: Transforming growth factor beta receptor; PI3K: Phosphatidylinositol 3-kinase.

Citation: Esteban-Jurado C, Garre P, Vila M, Lozano JJ, Pristoupilova A, Beltrán S, Abulí A, Muñoz J, Balaguer F, Ocaña T, Castells A, Piqué JM, Carracedo A, Ruiz-Ponte C, Bessa X, Andreu M, Bujanda L, Caldés T, Castellví-Bel S. New genes emerging for colorectal cancer predisposition. World J Gastroenterol 2014; 20(8): 1961-1971
URL: https://www.wjgnet.com/1007-9327/full/v20/i8/1961.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i8.1961