Telomeres, telomerase and colorectal cancer

doi:10.3748/wjg.v20.i8.1940

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Feb 28, 2014 (publication date) through Jul 10, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2014; 20(8): 1940-1950
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1940

Table 1 Telomeres and telomerase: outstanding questions regarding their role in the genesis and progression of colorectal cancer

Is the shortening of telomeres an early or late event in colorectal carcinogenesis?

Does telomere shortening play a role in genomic instability?

Do telomere lengths correlate with telomerase expression/activity?

Do telomere lengths correlate with disease progression?

Do levels of telomerase expression/activity increase with disease progression?

Do telomere and/or telomerase act as prognostic markers for disease outcome?

Citation: Bertorelle R, Rampazzo E, Pucciarelli S, Nitti D, Rossi AD. Telomeres, telomerase and colorectal cancer. World J Gastroenterol 2014; 20(8): 1940-1950
URL: https://www.wjgnet.com/1007-9327/full/v20/i8/1940.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i8.1940