Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice

Figure 6 CD4⁺ T-cell infiltration associated with Trichuris muris infection in the proximal colon of FVB (WT) and mdr1a-/- (PGP-KO) mice. A: Immunohistochemical staining for CD4⁺ T cells in naïve (WT-N; KO-N) and Trichuris muris (T. muris) infected (WT-INF; KO-INF) WT and PGP-KO mice; B: Mean data (± SD) from 5 animals in each group showing CD4⁺ T cells present per 20 crypts units. Tissues were isolated on day 19 post-infection in T. muris infected mice, ^bP < 0.01.