Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies

Table 1 Randomized controlled trials included in the meta-analysis

Study	Agent	All subjects	Duration (yr)	Incident colorectal cancer cases		RR	95%CI
				Statin group	Control group
JUPITER[43]	Rosuvastatin	16304	Median: 2.0	16 of 8154	28 of 8150	0.57	0.31-1.05
WOSCOPS[44]	Pravastatin	6577	Mean: 4.9	12 of 3291	20 of 3286	0.60	0.29-1.23
4S[47]	Simvastatin	4444	Median: 10.4	25 of 2221	32 of 2223	0.78	0.46-1.32
ALLHAT-LLT[46]	Pravastatin	10355	Mean: 4.8	461 of 5170	381 of 5185	1.21	0.79-1.86
HPS[45]	Simvastatin	20536	Mean: 5.0	114 of 10269	131 of 10267	0.87	0.68-1.12
LIPID[48]	Pravastatin	9014	Mean: 8.0	75 of 4512	71 of 4502	1.05	0.76-1.45
AFCAPS[5]	Lovastatin	6605	Mean: 5.2	251 of 3304	201 of 3301	1.25	0.70-2.24
CARE[4]	Pravastatin	4159	Mean: 4.8	12 of 2081	21 of 2078	0.57	0.28-1.16

¹Figures for colon cancer rather than colorectal cancer.