Modulation of hepatic steatosis by dietary fatty acids

Table 3 Effect of olive oil on liver lipid profile

Fatty acidcomposition (%)		Experimental design	Results	Ref.
C16:0 C16:1 C17:0 C18:0 C18:1 C18:2 C18:3 C20:0 C20:1 C24:0	11.80 0.90 0.40 2.80 79.20 3.50 0.60 0.30 0.20 0.40	Wistar rats fed for 12 wk with a diet containing 10% olive oil	↑ Hepatic lipids	Ruiz-Gutiérrez et al[69]
C16:0 C16:1 C17:0 C18:0 C18:1 C18:2 C18:3 C20:0 C20:1 C24:0	11.79 0.86 0.37 2.79 79.22 3.45 0.60 0.28 0.20 0.44	Spontaneously hypertensive rats fed for 12 wk with a diet containing 10% of energy as olive oil	↑ Hepatic lipids	Perona et al[70]
C16:0 C16:1 C18:0 C18:1 C18:2 C18:3 C20:0	11.87 0.94 2.92 77.26 5.69 0.50 0.39	Wistar rats fed for 4 wk with a diet containing 40% of energy as olive oil	↑ Hepatic lipids ↑De novo lipogenesis	Portillo et al[71]
C16:0 C18:0 C18:1 C18:2 C18:3	10.70 2.00 74.80 10.40 0.70	Wistar rats fed for 6 wk with a diet containing 20% olive oil	↑ Hepatic lipids ↑De novo lipogenesis	Takeuchi et al[72]
C16:0 C18:1 C18:2	11.29 71.26 9.76	Sprague-Dawley rats fed for 2 mo with a methionine choline-deficient diet containing olive oil (0.45 mg/g rat weight)	↓ Hepatic steatosis	Hussein et al[73]
C16:0 C18:0 C18:1 C18:2 C18:3	12.10 3.00 27.40 51.90 2.70	ICR mice fed for 8 wk with a diet containing 7.5% olive oil	↑ Hepatic lipids ↓ Fatty acid oxidation	Ferramosca et al[41]