Modulation of hepatic steatosis by dietary fatty acids

Table 2 Role of dietary fat in the development of hepatic steatosis

Dietary fat	Fatty acid composition (%)		Experimental design	Results	Ref.
Lard	C14:0 C16:0 C18:0 C18:1 C18:2	0.50 8.70 4.30 15.80 3.50	Sprague-Dawley rats fed for 12 wk with a high-fat diet (35% fat)	↑ Hepatic steatosis ↓ Fatty acid oxidation ↑ Haematic triglycerides ↑ Mitochondrial uncoupling ↑ Haematic insulin ↑ Haematic glucose	Ferramosca et al[42]
	CLA c-9, t-11 CLA t-10, c-12	0.004 0.40	C57Bl/6J mice fed were fed for 4 wk with a diet containing 0.4% CLA	↑ Hepatic steatosis ↑De novo lipogenesis ↑ Haematic insulin	Clément et al[64]
CLA	C16:0 C18:0 C18:1 C18:2 CLA c-9, t-11/ t-9, c-11 CLA t-10, c-12 CLA c-9, c-11/c10, c12 CLA t-9, t-11/t10, t12	5.91 0.60 5.27 1.22 0.49 0.51 0.03 0.02	C57BL/6J mice were fed for 21 days with a diet containing 1.5% CLA	↑ Hepatomegaly ↑ Hepatic steatosis ↑De novo lipogenesis ↑ Fatty acid oxidation	Takahashi et al[65]
	CLA t-10, c-12	1.00	C57BL/6J mice fed for 4 wk with a diet supplemented with 1% CLA	↑ Liver weight ↓ Haematic triglycerides ↓ Haematic FFA ↑ Fatty acid oxidation	Degrace et al[68]
	C16:0 C16:1 C18:0 C18:1 C18:2 CLA c-9, t-11 CLA t-10, c-12 CLA c-9, c-11/c10, c12 CLA t-9, t-11/t10, t12	5.94 0.01 0.60 5.30 1.27 0.49 0.51 0.03 0.02	ICR mice fed for 22 d with a diet containing 1.0% CLA	↑ Liver weight ↑ Hepatic steatosis ↑De novo lipogenesis ↑ Fatty acid oxidation ↑ Haematic insulin	Ide[66]
	C16:0 C18:0 C18:1 C18:2 C18:3 CLA c-9, t-11 CLA t-10, c-12	12.00 2.70 42.50 30.50 2.90 3.50 3.70	ICR mice fed for 16 wk with a diet containing 1% CLA	↑ Liver weight ↑ Hepatic steatosis ↑De novo lipogenesis ↑ Fatty acid oxidation ↓ Haematic triglycerides ↓ Haematic FFA	Ferramosca et al[44]
	C16:0 C18:0 C18:1 C18:2 C18:3 CLA c-9, t-11 CLA t-10, c-12	12.00 2.70 42.50 30.50 2.90 3.50 3.70	ICR mice fed for 16 wk with a diet containing 1% CLA	↑ Liver weight ↑ Hepatic steatosis ↑De novo lipogenesis ↑ Fatty acid oxidation ↓ Haematic triglycerides ↓ Haematic cholesterol ↑ Haematic insulin	Ferramosca et al[39]

CLA: Conjugated linoleic acids.