Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats

Figure 1 Histopathological examination of stomach sections. A: Hematoxylin-eosin stained results showed severe degenerative changes in glandular region, epithelial folds and connective septa in aspirin-induced mucosal tissue (1, × 100 and 2, × 200), while hydrogen-rich water (HRW) pretreatment displayed slight changes (3, × 100 and 4, × 200); B: The gastric mucosal damage score in four groups. The mean scores are significantly higher in the aspirin group and HRW plus aspirin group (HRW + Asp) when compared with the normal control group and HRW alone group (^bP < 0.01). Pretreatment with HRW could significantly decrease the damage score in HRW + aspirin group (Asp) group when compared with aspirin group (^aP < 0.05).