Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer

Table 7 Analysis of serum insulin, insulin-like growth factor-1, insulin-like growth factor binding proteins, and insulin-like growth factor-1/insulin-like growth factor binding protein-3 ratio

Stage	n	Insulin(mU/L)	IGF-1(μg/L)	IGFBP-1(μg/L)	IGFBP-3(μg/L)	IGF-1/IGFBP-3
T1	60
Pre-operation		7.85 ± 4.87	153.52 ± 32.65	8.25 ± 1.24	8.25 ± 3.25	18.61 ± 10.01
Post-operation		7.68 ± 5.07	151.46 ± 39.19	7.91 ± 4.66	9.65 ± 4.06	15.70 ± 9.65
P value		P > 0.05	P > 0.05	P > 0.05	P < 0.05	P < 0.05
T2	362
Pre-operation		10.51 ± 6.03	200.37 ± 52.45	11.95 ± 2.69	5.95 ± 3.26	33.68 ± 16.08
Post-operation		8.78 ± 8.07	148.58 ± 45.63	9.06 ± 4.31	8.84 ± 4.06	16.81 ± 11.01
P value		P < 0.05	P < 0.05	P < 0.05	P < 0.05	P < 0.05
T3	193
Pre-operation		11.25 ± 6.57	209.69 ± 48.11	12.25 ± 3.01	5.75 ± 3.86	36.47 ± 12.46
Post-operation		8.83 ± 8.07	150.78 ± 35.21	9.85 ± 3.66	8.63 ± 3.33	17.48 ± 10.57
P value		P < 0.05	P < 0.05	P < 0.05	P < 0.05	P < 0.05

IGF-1: Insulin-like growth factor-1; IFGBP-1: Insulin-like growth factor binding protein-1.