Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer

Table 6 Associations of waist-to-hip ratio and body mass index of colon cancer patients with the levels of leptin, insulin, insulin-like growth factor, insulin-like growth factor binding protein-1, insulin-like growth factor binding protein-3 and insulin-like growth factor-1/insulin-like growth factor binding protein-3 ratio

Biomarker	WHR Pearson correlation	BMI Pearson correlation	P value
Insulin	0.519	0.485	< 0.001 0.002
Leptin	0.396	0.448	< 0.001 < 0.001
IGF-1	0.394	0.172	> 0.05 > 0.05
IFGBP-1	-0.259	0.082	> 0.05 > 0.05
IGFBP -3	-0.443	-0.342	0.005 0.018
IGF-1/IGFBP3	0.501	0.296	0.045 0.050

IGF-1: Insulin-like growth factor-1; IFGBP-1: Insulin-like growth factor binding protein-1; WHR: Waist-to-hip ratio; BMI: Body mass index.