Current progress toward eradicating Helicobacter pylori in East Asian countries: Differences in the 2013 revised guidelines between China, Japan, and South Korea

Table 3 Regimens for Helicobacter pylori eradication in 2013 guidelines

	China	Japan	South Korea
First-line treatment1	Amoxicillin 1 g (or metronidazole 400 mg), clarithromycin 500 mg, and PPI twice daily for 7-14 d	Amoxicillin 750 mg, clarithromycin 200 mg (or 400 mg), and PPI twice daily for 7 d	Amoxicillin 1 g, clarithromycin 500 mg, and PPI twice daily for 7-14 d
Second-line treatment	Bismuth 220 mg, tetracycline 750 mg, metronidazole 400 mg twice, and PPI twice daily for 10 or 14 d	Amoxicillin 750 mg, metronidazole 250 mg, and PPI twice daily for 7 d	Bismuth 120 mg four times, tetracycline 500 mg four times, metronidazole 500 mg thrice, and PPI twice daily for 7-14 d

¹In China and South Korea, first-line treatment can be passed directly to second-line treatment using bismuth-based quadruple therapy in cases with a high clarithromycin resistance rate (> 15%-20%). PPI: Proton pump inhibitor.