Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms

Table 4 Correlation between stage of Helicobacter pylori-related chronic gatritis and risk of colorectal neoplasm

	H. pylori CAG	Controls (n = 239)	Total adenoma cases (n =239)	Proximal adenoma (n = 38)	Bilateral adenoma (n = 78)	Distal adenoma (n = 123)
Group A	(-) (-)	71	35	4	15	16
Group B	(+) (-)	105	127	18	41	68
	B1 (PG1/2 > 3)	92	103	14	34	55
	B2 (PG1/2 ≤ 3)	13	24	4	7	13
Group C	(+)	63	77	16	22	39
	C1 (PG1/2 > 2, PGI > 30)	50	53	11	15	27
	C2 (PG1/2 ≤ 2, PGI ≤ 30)	13	24	5	7	12
Adjusted OR1	(A:B) (95%CI)	1	2.81 (1.64-4.81)	3.06 (0.99-9.42)	1.85 (0.94-3.62)	3.05 (1.62-5.73)
	(A:B1) (95%CI)	1	2.36 (1.43-3.88)	2.73 (0.86-8.65)	1.74 (0.87-3.47)	2.86 (1.50-5.47)
	(A:B2) (95%CI)	1	3.78 (1.71-8.38)	5.32 (1.17-24.1)	2.66 (0.89-7.98)	4.36 (1.68-11.3)
Adjusted OR1	(A:C) (95%CI)	1	2.7 (1.58-4.62)	4.51 (1.43-14.2)	1.76 (0.83-3.74)	3.05 (1.54-6.07)
	(A:C1) (95%CI)	1	2.27 (1.29-3.99)	3.88 (1.17-12.9)	1.52 (0.67-3.45)	2.59 (1.25-5.35)
	(A:C2) (95%CI)	1	4.2 (1.88-9.40)	6.95 (1.63-29.6)	2.65 (0.87-8.05)	5.09 (1.89-13.7)

¹Adjusted for current smoking and total cholesterol by conditional logistic regression analysis. B1: Group αβ, subgroup based on less-strict criteria for PG I (≤ 70 ng/mL) and PG I/II ratio (> 3.0) or PG I (> 70 ng/mL) and PG I/II ratio (> 3.0) to detect mild inflammation; B2: Group γ, subgroup based on stricter criteria for PG I (> 70 ng/mL) and PG I/II ratio (≤ 3.0) to detect severe active inflammation; C1: Subgroup based on less strict criteria for PG I (≤ 70 ng/mL) and PG I/II ratio (≤ 3.0) to detect extensive CAG; C2: Subgroup based on stricter criteria for positive PG I (≤ 30 ng/mL) and PG I/II ratio (≤ 2.0) to detect more extensive and severe CAG; H. pylori: Helicobacter pylori; CAG: Chronic atrophic gastritis.