Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms

Table 3 Studies investigating correlations between progression of Helicobacter pylori -related chronic gatritis and risk of colorectal neoplasm

Ref.	Country	Year of publication	Type of study design	No. of subjects	Measure of H. pylori-related gastritis	Outcome	Crude OR (95%CI)	Adjusted OR (95%CI)
[17]	Japan	2011	Population-based	478	H. pylori IgG and PG test
			Case-control		[mild CAG (Group B)]	Adenoma	2.61 (1.54-4.11)	2.81 (1.64-4.81)
[17]	Japan	2011	Population-based	478	H. pylori IgG and PG test
			Case-control		[extensive CAG (Group C)]	Adenoma	2.3 (1.38-3.83)	2.7 (1.58-4.62)
					H. pylori IgG and stricter CAG criteria
					[more extensive CAG (Group C)]	Adenoma	3.75 (1.70-8.23)	4.2 (1.88-9.40)
[25]	United States	2012	Cross-sectional	100296	Histopathology	Adenoma	1.52 (1.46-1.57)	-
				57820	(H. pylori-related gastritis)	Advanced adenoma	1.8 (1.69-1.92)	-
				51067		Cancer	2.35 (1.98-2.80)	-
[25]	United States	2012	Cross-sectional	90953	Histopathology	Adenoma	1.82 (1.71-1.94)	-
				52802	(intestinal metaplasia)	Advanced adenoma	2.02 (1.82-2.24)	-
				46882		Cancer	2.55 (1.93-3.37)	-

H. pylori: Helicobacter pylori; IgG: Immunoglobulin G; PG: Pepsinogen; CAG: Chronic atrophic gastritis; OR: Odds ratio.