Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms

Table 2 Studies investigating correlations between Helicobacter pylori-related chronic atrophic gastritis diagnosed on the basis of pepsinogen tests and risk of colorectal neoplasm

Ref.	Country	Year of publication	Type of study design	No. of subjects	Measure of CAG status	Outcome	Crude OR or HR (95%CI)	Adjusted OR or HR (95%CI)
[14]	Japan	2007	Case-control	339	PG test	Cancer	-	OR = 1.56 (0.86-2.85)
[17]	Japan	2011	Population-based	478	PG test	Adenoma	OR 1.31 (0.89-1.93)	OR = 1.45 (0.97-2.17)
			Case-control
[24]	Italy	2012	Case-control	320	PG test + histopathology	Adenoma	-	OR = 0.59 (0.23-1.48)
						Cancer	-	OR = 1.03 (0.34-3.16)
[26]	Finland	2010	Cohort	20269	PG test + histopathology	Cancer	HR 1.00 (0.65-1.55)	HR = 0.98 (0.61-1.58)
[27]	Japan	2013	Cohort	99	PG test	Adenoma + Cancer	HR 2.02 (1.05-3.91)	HR = 2.72 (1.33-5.57)

CAG: Chronic atrophic gastritis; PG: Pepsinogen; OR: Odds ratio; HR: Hazard ratio.