Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series

Figure 1 Endoscopic and pathological features of early lymphoepithelioma-like gastric carcinoma treated by endoscopic submucosal dissection (Case 1). A: White light endoscopy image shows early lymphoepithelioma-like gastric carcinoma (LELC) with surface hyperemia; B: Image of the same sample after treatment with indigocarmine dye; C: Photomicrograph of LELC shows dense lymphocytic infiltration and a pushing margin (HE, × 50); D: Photomicrograph of Epstein-Barr virus-encoded RNA detected by in situ hybridization (× 50). Note the positive staining localized specifically to the nuclei of tumor cells, while no signal can be seen in the lymphocytes.