Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C

Table 4 Factors correlating with velocity of shear wave in 108 patients with chronic hepatitis C virus infection

	All patients (n = 108)				Patients with F0 or F1 (n = 31)				Patients with F2 (n = 32)				Patients with F3 or F4 (n = 45)
	Spearman's rank correlation test		Multiple regression analysis		Spearman's rank correlation test		Multiple regression analysis		Spearman's rank correlation test		Multiple regression analysis		Spearman's rank correlation test		Multiple regression analysis
	ρ	P value	β	P value	ρ	P value	β	P value	ρ	P value	β	P value	ρ	P value	β	P value
Age (yr)		NS				NS				NS				NS
Gender (female/male)1		NS				NS				NS				NS
BMI		NS			-0.608	0.0003	-0.033	0.0001		NS				NS
Fibrosis stage	0.732	< 0.0001	0.187	0.0001		NS							0.505	0.0004	0.292	0.0044
Inflammatory grade	0.612	< 0.0001		NS		NS				NS				NS
Steatosis grade		NS				NS				NS				NS
AST (IU/L)	0.430	< 0.0001		NS		NS				NS				NS
ALT (IU/L)	0.318	0.0008		NS	0.343	0.0593		NS		NS				NS
γ-GTP (IU/L)	0.407	< 0.0001		NS	0.340	0.0614		NS	0.544	0.0013	0.005	0.0012		NS
Platelet count (× 104/μL)	-0.441	< 0.0001		NS		NS				NS			-0.425	0.0036		NS
Prothrombin time (INR)	0.344	0.0003		NS		NS				NS			0.390	0.0080		NS
Albumin (g/dL)	-0.347	0.0002		NS		NS				NS			-0.459	0.0015		NS
Total cholesterol (mg/mL)	-0.337	0.0004		NS		NS				NS				NS
γ-globulin (g/dL)	0.252	0.0087		NS		NS			-0.344	0.0581		NS		NS
Hyaluronic acid (ng/mL)	0.576	< 0.0001	8.00E-4	0.0039		NS				NS			0.519	0.0003	0.001	0.0025
HCV genotype (1/2)1		0.0728		NS		NS				NS				NS
HCV RNA (logIU/mL)		NS				NS				NS				NS
Fibrosis area (%)	0.656	< 0.0001		NS		NS				NS			0.296	0.0481		NS
R			0.707				0.645				0.546				0.634
Adjusted R			0.490				0.396				0.275				0.373
F			51.800				20.700				12.700				14.100
P value			< 0.0001				0.0001				0.0012				< 0.0001

¹Difference of frequency of gender or genotype was assessed by Mann-Whitney U test. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyltranspeptidase.