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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 7, 2014; 20(5): 1192-1210
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1192
Table 1 Evidence for the role of specific major pathogens in the aetiopathogenesis of inflammatory bowel disease in the last decade n (%)
YearPathogenDiseaseSample typeDetection rate
Reference
CDUCControl
2003MAPCDTissue34/37 (92)9/34 (26)[85]
2003MAPCD and UCTissue0/24 (0)1/28 (4)6/19 (32)[94]
2003HelicobacterCD and UCTissue0/9 (0)0/11 (0)0/10 (0)[109]
2004MAPCD and UCBlood107/283 (37.8)50/144 (34.7)135/402 (33.6)[92]
2004MAPCD and UCBlood13/28 (46)4/9 (45)3/15 (20)[86]
2004H. pyloriUCTissue8/42 (19)7/74 (9.5)[110]
2004HelicobacterCD and UCTissue1/25 (4)5/33 (15.2)0/29 (0)[111]
2004HelicobacterCD and UCTissue0/30 (0)0/26 (0)0/25 (0)[112]
2004EHHCD and UCTissue3/25 (12)3/18 (17)1/23 (4)[113]
H. pullorum2/25 (8)0/18 (0)1/23 (4)
H. fennelliae1/25 (4)3/18 (17)0/23 (0)
H. pylori8/25 (32)5/18 (28)14/23 (61)
2004HelicobacterCD, UC and ICTissue0/11 (0)1/20 (5)0/37 (0)[114]
2004E. coliCD and UCTissue11/14 (79)8/21 (38)10/24 (42)[156]
AIEC10/14 (71)10/21 (48)7/24 (29)
2004AIECCDTissue7/63 (11.1)1/16 (6.3)[154]
2004E. coliCDTissue12/15 (80)1/10 (10)[158]
2006E. coliCD and UCTissue9/12 (75)7/7 (100)2/8 (25)[159]
2007AIECCD and UCTissue8/13 (61.5)11/19 (57.9)4/15 (26.7)[160]
2008HelicobacterCDFaeces17/29 (59)1/11 (9)[115]
EHH11/29 (38)1/11 (9)
H. pylori6/29 (21)0/11 (0)
H. trogontum4/29 (14)1/11 (9)
H. canis5/29 (17)0/11 (0)
H. bilis4/29 (14)0/11 (0)
H. cinaedi1/29 (3)0/11 (0)
2009AIECCDTissue14/27 (51.9)4/24 (16.7)[155]
2009HelicobacterCDTissue32/73 (43.8)43/92 (46.7)[116]
EHH18/73 (24.7)16/92 (17.4)
H. pylori29/73 (39.7)39/92 (42.4)
H. pullorum8/73 (11)6/92 (6.5)
H. canndensis10/73 (13.7)10/92 (10.9)
2009CampylobacterCDTissue27/33 (82)12/52 (23)[131]
C. concisus17/33 (51)1/52 (2)
C. showae3/33 (9)0/52 (0)
C. hominis2/33 (6)2/52 (4)
C. gracilis2/33 (6)0/52 (0)
C. rectus1/33 (3)2/52 (4)
C. jejuni1/33 (3)3/52 (6)
C. ureolyticus1/33 (3)2/52 (4)
2010HelicobacterCDTissue32/77 (41.6)23/102 (22.5)[117]
EHH18/77 (23.4)12/102 (11.8)
H. pylori14/77 (18.2)11/102 (10.8)
H. bilis1/77 (1.3)1/102 (1.0)
H. canis2/77 (2.6)0/102 (0.0)
H. hepaticus2/77 (2.6)2/102 (2.0)
H. trogontum5/77 (6.5)4/102 (3.9)
2010CampylobacterCDFaeces39/54 (72)10/33 (10)[132]
C. concisus35/54 (65)11/33 (33)
2010C. concisusCD and UCSaliva13/13 (100)5/5 (100)57/59 (97)[136]
2011HelicobacterUCTissue32/77 (42)11/59 (19)[118]
EHH30/77 (39)2/59 (3)
H. pylori2/77 (3)9/59 (15)
2011C. concisusCD, UC and ICTissue8/12 (66.7)3/8 (37.5)11/26 (42.3)[133]
2011CampylobacterUCTissue51/69 (73.9)15/65 (23.1)[135]
C. concisus23/69 (33.3)7/65 (10.8)
C. ureolyticus15/69 (21.7)2/65 (10.8)
C. hominis14/69 (20.3)5/65 (7.7)
C. curvus3/69 (4.3)4/65 (6.2)
C. showae4/69 (5.8)0/65 (0)
C. jejuni2/69 (2.9)0/65 (0)
C. gracilis1/69 (1.4)0/65 (0)
2011CampylobacterCD and UCTissue12/15 (80)11/13 (85)18/33 (48)[134]
C. concisus10/15 (67)9/13 (69)12/33 (36)
C. showae1/15 (7)2/13 (15)2/33 (6)
C. hominis1/15 (7)1/13 (8)3/33 (9)
C. ureolyticus2/15 (13)1/13 (8)2/33 (6)
C. gracilis1/15 (7)1/13 (8)0/33 (0)
C. rectus0/15 (0)1/13 (8)0/33 (0)
C. jejuni1/15 (7)0/13 (0)0/33 (0)
2012AIECCD and UCTissue1/17 (5.9)1/10 (10)0/23 (0)[166]
2013HelicobacterCD and UCTissue4/29 (13.8)1/13 (7.7)5/42 (11.9)[119]
H. brantae1/59 (3.4)0/13 (0)0/42 (0)
H. hepaticus1/59 (3.4)0/13 (0)0/42 (0)
2013CampylobacterCD and UCTissue22/29 (75.9)9/13 (69)32/42 (76.2)[119]
C. concisus13/29 (44.8)4/13 (30.8)16/42 (38.1)
C. curvus2/29 (6.9)0/13 (0)3/42 (7.1)
C. gracilis1/29 (3.4)0/13 (0)2/42 (4.8)
C. hominis9/29 (31.0)5/13 (38.5)14/42 (33.3)
C. rectus0/29 (0)0/13 (0)4/42 (9.5)
C. showae9/29 (31.0)5/13 (38.5)9/42 (21.4)
C. ureolyticus0/29 (0)0/13 (0)2/42 (4.8)