Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease

Table 1 Methylxanthines compared with common chitinase inhibitors in IC₅₀

Compound name	Chemical formula	IC50	Ref.
Caffeine	C8H10N4O2	469 ± 23 μmol/L against Aspergillus fumigatus (A. fumigatus) chitinase	[10]
Pentoxifylline	C13H18N4O3	126 ± 7 μmol/L against A. fumigatus chitinase	[10]
Theophylline	C7H8N4O2	1500 ± 90 μmol/L against A. fumigatus chitinase	[10]
Allosamidin	C25H42N4O14	10 μmol/L against Candida albicans chitinase	[42]
Argifin	C29H41N9O10	3.7 μmol/L against Lucilia cuprina (L. cuprina) chitinase	[78]
Argadin	C29H42N10O9	3.4 nmol/L at 20 °C against L. cuprina chitinase	[79]

IC₅₀: The half maximal inhibitory concentration.