Bifidobacterium infantis attenuates colitis by regulating T cell subset responses

Figure 7 mRNA expression of T cell-related cytokines from mesenteric lymph nodes of trinitrobenzene sulfonic acid-induced colitis mice fed high dose Bifidobacterium infantis. A: T-bet; B: IL-2; C: IFN-γ; D: IL-12p40; E: GATA3; F: IL-4; G: RORγt; H: IL-17A; I: IL-21; J: IL-23; K: Foxp3; L: IL-10; M: TGF-β. Real-time RT-PCR was employed to examine the expression of Th1, Th17 and Foxp3+ Treg related cytokines. PBS-TNBS: In the PBS-TNBS group, the animals were fed PBS before TNBS induction; Bifidobacterium infantis (B. infantis)-TNBS: In the B. infantis-TNBS group, the animals were fed high dose B. infantis before TNBS induction. Data are expressed as relative expression and the control group was chosen as the calibrator. Data are mean ± SE (n = 5, per group). ^aP < 0.05 vs PBS-TNBS, ^bP < 0.01 vs the control group. IL: Interleukin; IFN: Interferon; TNBS: Trinitrobenzene sulfonic acid.