Intravenous vs intraperitoneal mesenchymal stem cells administration: What is the best route for treating experimental colitis?

Figure 6 Intravenous administration of mesenchymal stem cells induced T cell apoptosis. A: Apoptosis rate. TUNEL-positive mononuclear cells were significantly more frequent in the DSS-MSC IV group when compared to the DSS-MSC IP and DSS groups; B: Apoptotic T cells were detected by immunohistochemical staining with anti-CD3 antibody; C: TUNEL assay showing fluorescent apoptotic cells after DSS administration. ^aP < 0.05 vs DSS group; ^cP < 0.05 vs DSS-MSC IV, n = 5 mice/group. Scale bar: 100 μm. TUNEL: Terminal deoxynucleotidyl transferase-mediated dUDP-biotin nick end labeling; DSS: Dextran sulfate sodium; MSC: Mesenchymal stem cell.