Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice

Figure 6 Activation of caspases and cytochrome C release in mice treated with carbon tetrachloride. Western blot analysis of A: Caspase-12; B: Caspase-3; C: Cytochrome C release from mitochondria; D: Casapse-9; E: Caspase-8; F: Actin as control in CCl₄-treated and control caspase-12^+/+ and caspase-12^-/- mice; G: Densitometric analyses of cytosolic cytochrome C and cleaved caspase-3 and -9 were performed from four independent Western blot experiments. The values were normalized to actin for each individual sample. Values are mean ± SE; ^aP < 0.05 vs CCl₄-treated caspase-12^+/+.