Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes

Figure 3 At eubiosis stage, the intestinal epithelium hosts a rich and equilibrated microbiota that promotes the barrier function. Microbial dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis. Moreover dysbiosis induces dysregulation of immune responses that cause inflammation promotion of carcinogenesis. SCFA: Small-chain fatty acids; E. coli: Escherichia coli.