Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer

Table 3 Univariate and multivariate analyses of various prognostic parameters in stage IV patients with colorectal cancer using Cox-regression analysis n (%)

Characteristics	Univariate analysis		Multivariate analysis
		P value	HR	95%CI	P value
Gender		0.258
Male	40 (56.3)
Female	31 (43.7)
Age (yr)		0.934
≤ 55	39 (54.9)
> 55	32 (45.1)
ARID1a expression		0.027	2.49	1.13-5.51	0.024
Negative	25 (35.2)
Positive	46 (64.8)
T stage		0.038	2.01	1.08-3.75	0.029
T1	1 (1.4)
T2	5 (7.0)
T3	43 (60.6)
T4	22 (31.0)
N stage		0.929
N0	12 (16.9)
N1	27 (38.0)
N2	32 (45.1)
Pathologic differentiation		0.458
Poor	17 (23.9)
Moderate	51 (71.8)
Well	3 (4.3)
Tumor size (cm)		0.261
≤ 5	43 (60.6)
> 5	28 (39.4)
Metastatic site		0.806
Single	52 (73.2)
Multiple	19 (26.8)
Metastasis limited to the liver		0.519
No	37 (52.1)
Yes	34 (47.9)
Resection of metastatic tumors1		0.002	0.33	0.16-0.67	0.002
No	21 (29.6)
Yes	50 (70.4)

¹Resection of metastasis: Including R0 and R1 resection of all metastatic tumors. ARID1A: AT-rich interactive domain 1A.