Evaluation of the 7th edition of the TNM classification in patients with resected esophageal squamous cell carcinoma

Table 2 Univariate and multivariate analyses of factors

	Univariate			Multivariate
	HR	95%CI	P-value	HR	95%CI	P-value
Gender Male Female	1.0000.829	0.690-0.996	0.046	1.0001.333	1.091-1.629	0.005
Age, yr ≤ 60 > 60	1.0001.183	1.009-1.390	0.039	1.0000.999	0.840-1.190	0.995
Cigarette smoking No Yes	1.0001.190	1.019-1.388	0.027	1.0000.949	0.805-1.119	0.537
Alcohol consumption No Yes	1.0001.070	0.903-1.268	0.431
(neo) adjuvant therapy No Yes	1.0001.634	1.386-1.927	< 0.001	1.0001.330	1.102-1.606	0.003
pT 1 2 3 4	1.0002.4874.1865.154	1.856-3.3313.219-5.4443.015-8.812	< 0.001< 0.001< 0.001	1.0001.9822.3031.150	1.254-3.1321.437-3.6930.518-2.549	0.0030.0010.732
pN 0 1 2 3	1.0001.2941.9393.500	1.073-1.5601.567-2.3992.650-4.624	0.007< 0.001< 0.001	1.0000.3610.2900.122	0.242-0.5380.145-0.5800.047-0.314	< 0.001< 0.001< 0.001
pM 0 1	1.0003.392	2.359-4.875	< 0.001	1.0000.789	0.231-2.689	0.704
Histologic grade G1 G2 G3	1.0001.0541.227	0.875-1.2710.995-1.513	0.5780.056	1.0000.9170.874	0.724-1.1610.681-1.123	0.4720.292
Cancer location Upper thoracic Middle thoracic Lower thoracic + GEJ	1.0001.2011.326	0.977-1.4761.043-1.685	1.2011.326	1.0000.8081.027	0.634-1.0310.758-1.392	0.0860.862
Type of surgical approach Right thoracic Left thoracic	1.0001.149	0.912-1.448	0.238
Length of tumor ≤ Mean > Mean	1.0001.075	0.916-1.262	0.374

HR: Hazard ratio; CI: Confidence interval.