Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease

doi:10.3748/wjg.v20.i48.18240

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2014; 20(48): 18240-18248
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18240

Table 5 Marker expression in relation to tumor stage and grade n (%)

Gene		Stage			Grade
Gene		Early (n = 18)	Late (n = 52)	P value	Low (n = 43)	High (n = 27)	P value
Telomerase	+++	2 (11.11)	24 (46.15)	0.019	8 (18.60)	18 (66.67)	< 0.001
	++	6 (33.33)	7 (13.46)		11 (25.58)	2 (7.41)
	-	10 (55.56)	21 (40.37)		24 (55.81)	7 (25.93)
MAGE1	+++	0 (0.00)	9 (17.31)	0.099	3 (6.98)	6 (22.22)	0.123
	++	8 (44.44)	25 (48.08)		20 (46.51)	13 (48.15)
	-	10 (55.56)	18 (34.62)		20 (46.51)	8 (29.63)
MAGE3	+++	2 (11.11)	22 (42.31)	< 0.001	6 (13.95)	18 (66.67)	< 0.001
	++	13 (72.22)	7 (13.46)		19 (44.19)	1 (3.70)
	-	3 (16.67)	23 (44.23)		18 (41.86)	8 (29.63)
CD133	+	0 (0.00)	28 (53.85)	< 0.001	9 (20.93)	19 (70.37)	< 0.001
CD133	-	18 (100.00)	24 (46.15)	< 0.001	34 (79.07)	8 (29.63)	< 0.001
CK19	+	10 (55.56)	52 (100.00)	< 0.001	35 (81.40)	27 (100.00)	< 0.017
CK19	-	8 (44.44)	0 (0.00)	< 0.001	8 (18.60)	0 (0.00)	< 0.017
CD90	+	6 (33.30)	31 (59.60)	0.015	9 (20.93)	19 (70.37)	< 0.001
CD90	-	12 (66.70)	11 (21.15)	0.015	34 (79.07)	8 (29.63)	< 0.001

CK: Cytokeratin; MAGE: Melanoma antigen encoding.

Citation: Bahnassy AA, Zekri ARN, El-Bastawisy A, Fawzy A, Shetta M, Hussein N, Omran D, Ahmed AAS, El-Labbody SS. Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease. World J Gastroenterol 2014; 20(48): 18240-18248
URL: https://www.wjgnet.com/1007-9327/full/v20/i48/18240.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i48.18240