Non invasive tools for the diagnosis of liver cirrhosis

Table 3 Diagnostic reliability acoustic radiation force impulse for liver fibrosis and optimal cut-offs

Ref.	Patients analyzed by ARFI (n)	Etiology	F≥2				F≥3				F = 4
			Cut-off m/s	Se%	Sp%	AUROC	Cut-off m/s	Se%	Sp%	AUROC	Cut-off m/s	Se%	Sp%	AUROC
Fierbinteanu-Braticevici et al[159]	74	HCV	1.22	100	71	0.91	1.54	97	100	0.99	1.94	100	98	0.99
Friedrich-Rust et al[160]	81	HCV/HBV	1.37	69	92	0.82	1.45	84	86	0.91	1.75	82	91	0.91
Lupsor et al[161]	102	HCV	1.34	68	93	0.86	1.61	79	95	0.91	2.00	80	95	0.94
Yoneda et al[162]	54	NASH					1.77	100	91	0.97	1.91	100	96	0.98
Piscaglia et al[156]	70	Mixed	1.63	59	100	0.79	1.67	75	97	0.91	1.87	81	91	0.91
Rizzo et al[163]	139	HCV	1.31	81	70	0.86	1.71	91	86	0.94	2.11	83	86	0.89
Sporea et al[164]	199	Mixed	1.27	89	68	0.89	1.56	80	89	0.88	1.71	93	87	0.93
Sporea et al[154]	93	Mixed	1.41	71	78	0.77	1.69	73	88	0.79	1.81	100	88	0.92
Sporea et al[165]	911	HCV	1.33	69	80	0.80	1.43	75	81	0.82	1.55	84	76	0.84

Se: Sensitivity; Sp: Specificity; AUROC: Area Under Receiver Operating Characteristic; F: METAVIR fibrosis stage; ARFI: Acoustic radiation force impulse; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NASH: Nonalcoholic steatohepatitis.