Fluid resuscitation in acute pancreatitis

Table 2 Summary of available studies to date on controlled fluid therapy

Ref.	Year	Type of study (sample size)	Conclusion
Mao et al[16]	2010	RCT (n = 155)	Rapid hemodilution increases incidence of sepsis within 28 d and in-hospital mortality. Hematocrit should be maintained between 30% and 40% in acute response stage
Mao et al[17]	2009	RCT (n = 76)	Controlled fluid resuscitation offers better prognosis in patients with severe volume deficit within72 h of severe acute pancreatitis onset
Eckerwall et al[15]	2006	Retrospective cohort (n = 99)	Patients receiving 4000 mL or more of fluid in first 24 h developed more respiratory complications
Madaria et al[14]	2011	Retrospective cohort (n = 247)	Administration of > 4.1 L but not < 3.1 L was significantly associated with more local and systemic complications
Kuwabara et al[75]	2011	Retrospective (n = 9489)	Fluid volume during first 48 h was higher in patients requiring ventilation and higher mortality in acute pancreatitis

RCT: Randomized controlled trial.