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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2014; 20(47): 17914-17923
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17914
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17914
Figure 6 Role of microRNA-185 in the regulation of insulin signalling transduction and lipid metabolism.
MicroRNA-185 up-regulates the key effector insulin receptor substrate-2 (IRS-2), which in turn activates the phosphatidylinositide 3-kinase/Akt2 signalling that increases insulin sensitivity. On the other hand, miR-185 represses SREBP-1c and 2, which ultimately results in decreased lipid synthesis. SREBP-1C: Sterol-regulatory element-binding proteins 1C; SREBP-2: Sterol-regulatory element-binding proteins 2; FAS: Fatty acid synthase.
- Citation: Wang XC, Zhan XR, Li XY, Yu JJ, Liu XM. MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20(47): 17914-17923
- URL: https://www.wjgnet.com/1007-9327/full/v20/i47/17914.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i47.17914