MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease

Figure 5 MicroRNA-185 regulates the insulin signalling pathway in HepG2 cells. A: The HepG2 cells were transfected with pre-miR-185 or pre-miR control and, after 48 h, the protein expression levels of insulin receptor substrate (IRS)-1, IRS-2, phosphatidylinositide 3-kinase (PI3K) and Akt2 were detected by Western blot; B: Effect of miR-185 on Akt2 and PI3K phosphorylation. miR-185: microRNA-185.