HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells

Figure 1 Effects of hypoxia inducible factor-1α knockdown on regulation of esophageal cancer cell viability and migration. A: MTT assay demonstrated that Eca109/HIF-1α shRNA and TE13/HIF-1α shRNA cells proliferated slower than normal Eca109 and TE13 cells or Eca109 HIF-1α Neo and TE13 HIF-1α Neo cells; B: Transwell migration assay demonstrated that Eca109/HIF-1α shRNA and TE13/HIF-1α shRNA cells invaded slower than normal Eca109 and TE13 cells or Eca109 HIF-1α Neo and TE13 HIF-1α Neo cells. Expression of HIF-1α and the four VM-related genes in TE13/shHIF and Eca109/shHIF cells under hypoxia vs under normoxia, ^aP < 0.05. HIF: Hypoxia inducible factor.