Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma

Figure 4 G₀S₂ expression was validated by quantitative polymerase chain reaction in the independent samples. The results are shown as the mean ± SE. -ΔCTG₀S₂ represents the expression level of G₀S₂. The differences of -ΔCTG₀S₂ in the 4 groups [low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), early-stage adenocarcinoma (EGC) and gastritis] were compared using an analysis of variance (one-way ANOVA). A test for the homogeneity of variances shows P = 0.105, indicating that the variances are equal. The mean difference between LGIN and HGIN was statistically significant (P = 0.004). The mean difference between LGIN and EGC was statistically significant (P < 0.001).