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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2014; 20(47): 18001-18012
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18001
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18001
Table 2 Percentage of cases with grade 3 or 4 toxicity n (%)
| Ref. | Treatment | Leukopenia | Neutropenia | Anemia | Thrombo-cytopenia | Increased ALT level | Nausea | Vomiting | Anorexia | Diarrhea |
| Valle et al[10] | GEM + CIS | 15.7 | 25.3 | 7.6 | 8.6 | 9.6 | 4.0 | 5.1 | 3.0 | NR |
| GEM | 9.5 | 16.6 | 3.0 | 6.5 | 17.1 | 3.5 | 5.5 | 2.5 | NR | |
| Okusaka et al[18] | GEM + CIS | 29.3 | 56.1 | 36.6 | 39.0 | 24.4 | 0.0 | 0.0 | 0.0 | 2.4 |
| GEM | 19.0 | 38.1 | 16.6 | 7.2 | 16.7 | 0.0 | 0.0 | 2.8 | 0.0 | |
| Sasaki et al[12] | GEM + S-1 | 33.0 | 33.0 | 10.0 | 7.0 | 3.0 | 3.0 | 0.0 | 3.0 | 0.0 |
| GEM | 19.0 | 22.0 | 6.0 | 6.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | |
| Kornek et al[14] | GEM + MMC | 17.0 | 13.0 | 0.0 | 13.0 | 40.0 | 44.0 | NR | NR | 28.0 |
| MMC + CAPE | 17.0 | 17.0 | 0.0 | 17.0 | 45.0 | 42.0 | NR | NR | 28.0 | |
| Sharma et al[17] | GEM + OX | 38.5 | 38.5 | 38.5 | 10.0 | 15.4 | NR | 7.7 | NR | NR |
| FUFA | 7.1 | 7.1 | 7.1 | 2.0 | 0.0 | NR | 7.1 | NR | NR | |
| Kang et al[11] | GEM + CIS | 24.4 | 49.0 | 22.4 | 22.4 | 4.1 | 4.1 | 4.1 | 0.0 | 0.0 |
| S-1 + CIS | 0.0 | 31.8 | 2.3 | 4.5 | 0.0 | 2.1 | 0.0 | 0.0 | 4.3 | |
| Morizane et al[13] | GEM + S-1 | 29.4 | 60.7 | 11.8 | 11.8 | 13.7 | 2.0 | 2.0 | 7.8 | 2.0 |
| S-1 | 2.0 | 4.0 | 4.0 | 4.0 | 12.0 | 4.0 | 0.0 | 6.0 | 6.0 |
- Citation: Liu H, Zhang QD, Li ZH, Zhang QQ, Lu LG. Efficacy and safety of gemcitabine-based chemotherapies in biliary tract cancer: A meta-analysis. World J Gastroenterol 2014; 20(47): 18001-18012
- URL: https://www.wjgnet.com/1007-9327/full/v20/i47/18001.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i47.18001