Poor agreement between endoscopists and gastrointestinal pathologists for the interpretation of probe-based confocal laser endomicroscopy findings

Table 2 Comparison of diagnostic accuracy between endoscopists and pathologist

	Lesion site	Sensitivity (95%CI)	Specificity (95%CI)	PPV(95%CI)	NPV(95%CI)	Accuracy (95%CI)
Endoscopist	All lesion types	87.0	80.0	90.9	72.7	84.8
		(77.2-96.7)	(62.4-97.5)	(82.4-99.4)	(54.1-91.3)	(76.2-93.5)
	Luminal1	82.4	92.9	96.6	68.4	85.4
		(69.5-95.2)	(66.1-99.8)	(82.2-99.9)	(47.5-89.3)	(75.4-95.4)
	Ampulla/PB	100	50.0	80.0	100	83.3
		(73.5-100)	(11.8-88.2)	(51.9-95.7)	(29.2-100)	(58.6-96.4)
Pathologist	All lesion types	69.6	40.0	72.7	36.4	60.6
		(56.3-82.9)	(18.5-61.5)	(59.6-85.9)	(16.3-56.5)	(48.8-72.4)
	Luminal1	64.7	42.9	73.3	33.3	58.3
		(48.6-80.8)	(16.9-68.8)	(57.5-89.2)	(11.6-55.1)	(44.4-72.2)
	Ampulla/PB	83.3	33.3	71.4	50.0	66.7
		(51.6-97.9)	(4.3-77.7)	(41.9-91.6)	(6.8-93.2)	(41.0-86.7)
P value for overall rates:		-	-	-	-	< 0.0012
P value for luminal lesions:		-	-	-	-	< 0.0012
P value for PB lesions:		-	-	-	-	0. 3752

¹Luminal lesions include lesions located in the esophagus, stomach and colon.

²P values were calculated using the McNemar’s test to compare the diagnostic accuracy between endoscopist and pathologist. P values cannot be calculated for sensitivity, specificity, NPV or PPV. PPV: Positive predictive value; NPV: Negative predictive value; PB: Pancreaticobiliary.