Cost-effectiveness analysis of colon cancer treatments from MOSIAC and No. 16968 trials

Table 1 Parameters used for calculation

	Value
Parameters	FOLFOX4	Data source	XELOX
Overall toxicity after adjuvant chemotherapy
Percentage of major toxicity state Pma	50.9%	43.0%	Andréand others, 2004
Percentage of minor toxicity state Pmi	41.1%	55.0%	Hans-Joachim Schmoll and others, 2007
Percentage of well state Pw	8.0%	2.0%
Percentage of death due to adjuvant chemotherapy Pd	0.5%	0.6%
Percentage of quitting adjuvant chemotherapy Pq	25.3%	22.0%
Probability of well state to well state Pw-w	0.66	0.52	Mehmet US Ayvaci and others, 2012
Probability of well state to minor toxicity state Pw-mi	0.31	0.46
Probability of well state to major toxicity state Pw-ma	0.03	0.02
Probability of minor toxicity state to well state Pmi-w	0.36	0.32
Probability of minor toxicity state to minor toxicity state Pmi-mi	0.32	0.40
Probability of minor toxicity state to major toxicity state Pmi-ma	0.32	0.28
Probability of major toxicity state to well state Pma-w	0.10	0.10
Probability of major toxicity state to minor toxicity state Pma-mi	0.39	0.49
Probability of major toxicity state to major toxicity state Pma-ma	0.30	0.20
Probability of major toxicity state to quitting adjuvant chemotherapy Pma-q	0.20	0.20
Probability of major toxicity state to death due to adjuvant chemotherapy Pma-d	0.01	0.01