Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma

Table 3 Enriched Gene Ontology terms of the upregulated transcripts in high-grade intraepithelial neoplasia compared with low-grade intraepithelial neoplasia

GO accession	GO term	P value	Genes involved
GO:0043170|GO:0043283	Macromolecule metabolic process	4.01 × 10-9	272
GO:0044260|GO:0034960	Cellular macromolecule metabolic process	3.84 × 10-9	247
GO:0006952|GO:0002217|GO:0042829	Defense response	9.44 × 10-8	63
GO:0005515|GO:0045308	Protein binding	1.09 × 10-7	358
GO:0044422	Organelle part	3.35 × 10-7	292
GO:0044428	Nuclear part	4.51 × 10-7	145
GO:0044446	Intracellular organelle part	4.17 × 10-7	288
GO:0070013	Intracellular organelle lumen	5.50 × 10-6	144
GO:0043122	Regulation of I-κB kinase/NF-κB cascade	6.79 × 10-6	21
GO:0043123	Positive regulation of I-κB kinase/NF-κB cascade	9.53 × 10-6	18

NF-κB: Nuclear factor-κB; GO: Gene ontology.