Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells

doi:10.3748/wjg.v20.i47.17863

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2014; 20(47): 17863-17876
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17863

Table 3 Top 10 up or down-regulated genes induced by tumor necrosis factor α in control small interfering RNA or claudin 1 small interfering RNA transfected MKN28 cells

Gene symbol	Gene ID	Gene name	Control siRNA	Claudin1 siRNA
Gene symbol	Gene ID	Gene name	Fold change	Fold change
Up-regulated genes
IL6	NM_000600	Interleukin 6	11.16	7.16
MMP9	NM_004994	Matrix metallopeptidase 9	10.49	18.13
BMP2	NM_001200	Bone morphogenetic protein 2	10.12	5.62
VSTM1	NM_198481	V-set and transmembrane domain containing 1	9.83	2.53
CLEC1A	NM_016511	C-type lectin domain family 1, member A	9.71	-1.22
CXCL10	NM_001565	Chemokine (C-X-C motif) ligand 10	9.33	1.82
IL2RG	NM_000206	Interleukin 2 receptor, gamma	9.14	15.56
TFPI	NM_001032281	Tissue factor pathway inhibitor	8.98	11.79
KLHDC7B	NM_138433	Kelch domain containing 7B	8.90	1.79
CCL5	NM_002985	Chemokine (C-C motif) ligand 5	8.85	7.84
Down-regulated genes
LY6G6F	NM_001003693	Lymphocyte antigen 6 complex, locus G6F	-311.81	1.05
RFTN2	NM_144629	Raftlin family member 2	-291.41	1.39
WT1	NM_024426	Wilms tumor 1	-75.96	1.05
MADCAM1	NM_130760	Mucosal vascular addressin cell adhesion molecule 1	-67.39	1.06
SLC2A9	NM_001001290	Solute carrier family 2, member 9	-49.12	-1.21
C10orf47	NM_153256	Chromosome 10 open reading frame 47	-44.11	1.85
SYNPR	NM_144642	Synaptoporin	-40.64	1.08
GGT7	NM_178026	Gamma-glutamyltransferase 7	-40.33	1.24
LRRC36	NM_018296	Leucine rich repeat containing 36	-38.25	1.06
MAS1L	NM_052967	MAS1 oncogene-like	-32.62	1.07

Citation: Shiozaki A, Shimizu H, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Nako Y, Liu M, Otsuji E. Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells. World J Gastroenterol 2014; 20(47): 17863-17876
URL: https://www.wjgnet.com/1007-9327/full/v20/i47/17863.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i47.17863