Original Article
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 21, 2014; 20(47): 17863-17876
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17863
Table 1 Genes that displayed the greatest changes in their expressions in the claudin 1 small interfering RNA transfected MKN28 cells
Gene symbolGene IDGene nameFold change
Up-regulated genes
FGF6NM_020996Fibroblast growth factor 6151.34
TM4SF20NM_024795Transmembrane 4 L six family member 2072.03
B4GALNT2NM_153446Beta-1,4-N-acetyl-galactosaminyl transferase 247.30
SLC2A13BC047507Solute carrier family 2 (facilitated glucose transporter), member 1343.02
HS3ST2NM_006043Heparan sulfate (glucosamine) 3-O-sulfotransferase 228.39
ZNF596NM_001042416Zinc finger protein 59626.36
IL2RANM_000417Interleukin 2 receptor, alpha22.00
CCL2NM_002982Chemokine (C-C motif) ligand 218.05
SGOL2BC048349Shugoshin-like 217.64
SYT4NM_020783Synaptotagmin IV17.29
FGF19NM_005117Fibroblast growth factor 1916.44
ARID5BNM_032199AT rich interactive domain 5B14.47
DEFB105BNM_001040703Defensin, beta 105B14.34
DSG3NM_001944Desmoglein 312.99
RSPH1NM_080860Radial spoke head 1 homolog (Chlamydomonas)12.82
COL5A2NM_000393Collagen, type V, alpha 212.72
NRG2NM_013982Neuregulin 212.63
TMEM26NM_178505Transmembrane protein 2612.22
CCL3L3NM_001001437Chemokine (C-C motif) ligand 3-like 311.54
OR51E1NM_152430Olfactory receptor, family 51, subfamily E, member 19.43
Down-regulated genes
LY6G6FNM_001003693Lymphocyte antigen 6 complex, locus G6F-332.04
WT1NM_024426Wilms tumor 1-68.28
MADCAM1NM_130760Mucosal vascular addressin cell adhesion molecule 1-60.84
SLC2A9NM_001001290Solute carrier family 2 (facilitated glucose transporter), member 9-48.05
SULT4A1NM_014351Sulfotransferase family 4A, member 1-39.30
SYNPRNM_144642Synaptoporin-36.73
C10orf47NM_153256Chromosome 10 open reading frame 47-29.96
MAS1LNM_052967MAS1 oncogene-like-29.67
CLDN1NM_021101Claudin 1-26.87
CBX1NM_006807Chromobox homolog 1-26.37
MPPED2NM_001145399Metallophosphoesterase domain containing 2-25.00
SCUBE2NM_020974Signal peptide, CUB domain, EGF-like 2-22.13
CHI3L2NM_001025199Chitinase 3-like 2-21.67
SLIT2NM_004787Slit homolog 2-21.60
HFM1NM_001017975HFM1, ATP-dependent DNA helicase homolog-20.56
CR1NM_000651Complement component (3b/4b) receptor 1-18.04
PLA2G10NM_003561Phospholipase A2, group X-16.70
GRIP2NM_001080423Glutamate receptor interacting protein 2-16.45
XISTNR_001564X (inactive)-specific transcript-15.79
TNF-SF10NM_003810Tumor necrosis factor (ligand) superfamily, member 10-15.26