Dendritic cells in hepatitis C virus infection: Key players in the IFNL3-genotype response

Table 1 Subsets of human dendritic cells

	Plasmacytoid dendritic cells	Myeloid dendritic cells
Morphology	Round, resemble plasma cells	Prominent cytoplasmic protrusions
Phenotype	CD11C- CD1a+	CD11c+ CD1a+
	CD123high	CD123low
		mDC1	mDC2
	BDCA-4+ (CD304+)
	BDCA-2+ (CLEC4C)	BDCA-1+ (CD1c+)	BDCA-3+ (CD141+)
			CLEC9A
TLR receptor expression	TLR1, TLR6, TLR7, TLR9, TLR10	TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8,TLR10	TLR1, TLR2, TLR3,TLR6, TLR8, TLR10
MHC I	+	++	++
MHC II	+	+++	++
CD86	+	+++	++
CD40	+	++	+++
CXCR3	+++	+	++
ICOS L	++	+	+++

mDC: Myeloid dendritic cell; BDCA: Blood dendritic cell antigen; TLR: Toll like receptor; MHC: Major histocompatibility complex; CXCR3: Chemokine receptor 3; ICOSL: Inducible costimulator ligand.