Toll-like receptor signaling in colorectal cancer: Carcinogenesis to cancer therapy

Table 3 Summary of therapy in colorectal cancer

Compound	Target (agonist)	Indications	Drug class or trade	Clinical phase
BCG[10,71,72]	TLR2/4	CRC	Synthetic ssRNA	Phase I
MPL[10,72]	TLR4	CRC	Synthetic ssRNA	Phase I
CBLB502[1,23,71]	TLR5	Colon cancer	Flagellin	Phase I
Imiquimod (Aldara)[10,71,72]	TLR7	CRC	Small molecule ssRNA	Phase I/II/III
IMO2055[1,10]	TLR9	CRC	CpG oligonucleotide	Phase I/II
MGN1703[16]	TLR9	CRC	dSLIM	Phase II