Toll-like receptor signaling in colorectal cancer: Carcinogenesis to cancer therapy

doi:10.3748/wjg.v20.i47.17699

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2014; 20(47): 17699-17708
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17699

Table 2 Toll-like receptors role in colorectal cancer

TLR	Carcinogenesis	Prognosis	Treatment
TLR2	Controversial role in mouse model; protective against development of CRC in colitis	Associated with survival after diagnosis of colon cancer	HMGB1, S100A9
TLR4	Oncogenic effects in vitro and in vivo	Poor progression	HMGB1, S100A9, MPLA
TLR9	Remain unclear; possible protection against malignant transformation in colorectal mucosa		CpG-ODN

CRC: Colorectal cancer; TLR: Toll Like receptor.

Citation: Li TT, Ogino S, Qian ZR. Toll-like receptor signaling in colorectal cancer: Carcinogenesis to cancer therapy. World J Gastroenterol 2014; 20(47): 17699-17708
URL: https://www.wjgnet.com/1007-9327/full/v20/i47/17699.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i47.17699