Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma

Figure 1 Immunohistochemical staining of liver fatty acid-binding protein in hepatocellular carcinoma. A: Representative liver fatty acid-binding protein (L-FABP)-negative case of hepatocellular carcinoma (HCC) identified by examination using tissue microarrays; B: Representative L-FABP-positive case of HCC identified by examination using tissue microarrays; C: Focal downregulation of L-FABP expression was observed in a case of small HCC (white arrows show the boundary between L-FABP-negative and L-FABP-positive areas, and black arrows show the boundary between tumorous and non-tumorous areas); D: Diffuse downregulation was observed in a case of large HCC (black arrows show the boundary between tumorous and non-tumorous areas).