T3-induced liver AMP-activated protein kinase signaling: Redox dependency and upregulation of downstream targets

Figure 4 Schematic representation of T₃ signaling related to AMPK upregulation and consequent fatty acid oxidation enhancement. ACC: Acetyl-CoA carboxylase; ACOT2: acyl-CoA thioesterase 2; ACOX1: acyl-CoA oxidase 1; AMPK: AMP-activated protein kinase; CaMKKβ: Ca²⁺-calmodulin-dependent protein kinase kinase-β; CBP/p300: CREB-binding protein; CPT-1α: Carnitine palmitolytransferase-1α; CREB: cAMP-response element-binding protein; FA: Fatty acid; PGT-1α: Peroxisome proliferator-activated receptor-γ coactivator-1α; QO₂: Rate of oxygen consumption; ROS: Reactive oxygen species; TAK1: Transforming growth factor-β-activated kinase-1.