Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure

Figure 3 Serum biochemistry. Before and after D-galactosamine injection, serum concentrations of total bilirubin (TBiL), total bile acid (TBA), ammonia, blood urea nitrogen (BUN) and creatinine (Cr) were significantly increased, whereas Fischer indices were significantly reduced. Six hours after treatment in the acute liver failure (ALF) group, levels of TBiL, TBA, ammonia, BUN, and Cr remained elevated, while the Fischer indices remained decreased. Additionally, in the hybrid bioartificial liver support system (HBALSS) group, levels of TBiL, TBA, ammonia, BUN and Cr decreased significantly. ^aP < 0.05 vs control group.